to make a breakthrough
scientist +有重大发现；取得突破性进展；company, entrepreneur +取得重大成就；实现重大突破
The company looks poised to make a significant breakthrough in China.该公司看来很有把握在中国市场取得重大突破。
Detectives made a breakthrough in the long-running case when the man's DNA was taken in quite a different matter.当警探们从一种完全不同的物质中提取到该男子的DNA后, 这个历时长久的案件终于取得了突破性进展。